ANTICANCER AGENTS from NATURAL PRODUCTS

[Year : 2005] [Size : 40.2 MB] [Format : PDF] [Pages : 569]

Editor
Gordon M. Cragg
David G.I. Kingston
David J. Newman

ANTICANCER AGENTS from NATURAL PRODUCTS

Line of Contents

  • Introduction
  • Camptothecin and Its Analogs
  • The Discovery and Development of the Combretastatins
  • Homoharringtonine and Related Compounds
  • Podophyllotoxins and Analogs
  • Taxol and Its Analogs
  • The Vinca Alkaloids
  • The Bryostatins
  • The Isolation, Characterization, and Development of a Novel Class of Potent Antimitotic Macrocyclic Depsipeptides: The Cryptophycins
  • Chemistry and Biology of the Discodermolides, Potent Mitotic Spindle Poisons
  • The Dolastatins: Novel Antitumor Agents from Dolabella auricularia
  • Ecteinascidin 743 (ET-743; Yondelis™), Aplidin, and Kahalalide F
  • Discovery of E7389, a Fully Synthetic Macrocyclic Ketone Analog of Halichondrin B
  • HTI-286, A Synthetic Analog of the Antimitotic Natural Product Hemiasterlin
  • The Actinomycins
  • Anthracyclines
  • Ansamitocins (Maytansinoids)
  • Benzoquinone Ansamycins
  • Bleomycin Group Antitumor Agents
  • Biochemical and Biological Evaluation of (+)-CC-1065 Analogs and Conjugates with Polyamides
  • Epothilone, a Myxobacterial Metabolite with Promising Antitumor Activity
  • Enediynes
  • The Mitomycins
  • Staurosporines and Structurally Related Indolocarbazoles as Antitumor Agents
  • Combinatorial Biosynthesis of Anticancer Natural Products
  • Developments and Future Trends in Anticancer Natural Products Drug Discovery


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